Melanie J Percy Selected Research

Polycythemia (Erythrocytosis)

1/2014	The role of PHD2 mutations in the pathogenesis of erythrocytosis.
6/2013	Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation.
1/2011	The HIF pathway and erythrocytosis.
7/2010	Regulation of human metabolism by hypoxia-inducible factor.
5/2010	Erythrocytosis associated with a novel missense mutation in the HIF2A gene.
11/2009	A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses.
9/2009	Identification of high oxygen affinity hemoglobin variants in the investigation of patients with erythrocytosis.
4/2009	Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.
6/2008	Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis.
5/2008	Familial erythrocytosis arising from a gain-of-function mutation in the HIF2A gene of the oxygen sensing pathway.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Melanie J Percy Research Topics

Disease

20	Polycythemia (Erythrocytosis) 01/2014 - 09/2003
17	Hypoxia (Hypoxemia) 01/2018 - 09/2003
4	primary familial and congenital Polycythemia 01/2014 - 01/2006
3	Cyanosis 07/2009 - 01/2004
2	Neoplasms (Cancer) 01/2018 - 04/2010
2	Anemia 04/2010 - 01/2006
2	Congenital Methemoglobinemia 07/2009 - 11/2002
2	Myeloproliferative Disorders (Myeloproliferative Disorder) 06/2007 - 09/2005
2	Primary Myelofibrosis (Myelosclerosis) 06/2007 - 09/2005
1	Adenocarcinoma 08/2011
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2011
1	Acidosis 07/2010
1	Breast Neoplasms (Breast Cancer) 04/2010
1	Sickle Cell Anemia (Hemoglobin S Disease) 01/2008
1	Pulmonary Hypertension 01/2008
1	Hemolysis 01/2008
1	Thalassemia 01/2008
1	Hyperplasia 12/2007
1	Essential Thrombocythemia 06/2007
1	Chronic Neutrophilic Leukemia 12/2005
1	Methemoglobinemia 11/2002

Drug/Important Bio-Agent (IBA)

14	Erythropoietin FDA Link 01/2018 - 09/2003
12	Oxygen (Dioxygen)IBA 01/2014 - 09/2003
8	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2018 - 01/2006
7	Transcription Factors (Transcription Factor)IBA 01/2014 - 01/2006
5	Proteins (Proteins, Gene)FDA Link 01/2014 - 05/2006
4	EnzymesIBA 01/2014 - 01/2006
4	Protein Isoforms (Isoforms)IBA 06/2013 - 01/2008
3	Hemoglobins (Hemoglobin)IBA 01/2014 - 01/2008
3	endothelial PAS domain-containing protein 1IBA 06/2008 - 10/2007
2	IronIBA 01/2014 - 10/2007
2	Von Hippel-Lindau Tumor Suppressor ProteinIBA 01/2011 - 05/2006
2	Cytochrome-B(5) Reductase (Methemoglobin Reductase)IBA 07/2009 - 11/2002
2	NAD (NADH)IBA 07/2009 - 11/2002
2	Valine (L-Valine)FDA Link 06/2007 - 09/2005
2	Phenylalanine (L-Phenylalanine)FDA Link 06/2007 - 09/2005
1	Iron Regulatory Protein 1IBA 01/2018
1	Mixed Function Oxygenases (Monooxygenases)IBA 01/2014
1	OxygenasesIBA 01/2014
1	Ketoglutaric Acids (Ketoglutaric Acid)IBA 01/2014
1	2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)IBA 01/2014
1	UbiquitinIBA 08/2011
1	Small Interfering RNA (siRNA)IBA 08/2011
1	Phosphocreatine (Neoton)IBA 07/2010
1	Lactic Acid (Lactate)FDA LinkGeneric 07/2010
1	HematinicsIBA 04/2010
1	LigandsIBA 11/2009
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 07/2009
1	MethemoglobinIBA 07/2009
1	Proline (L-Proline)FDA Link 04/2009
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2008
1	ElementsIBA 10/2007
1	CytokinesIBA 06/2007
1	Janus Kinase 2IBA 04/2007
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 05/2006
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2005
1	Janus KinasesIBA 09/2005
1	Dihydrotachysterol (AT 10)IBA 01/2004